Home / Research Areas / Signaling Pathways / PI3K/AKT/mTOR Pathway

PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR pathway is a central regulator of cell growth, metabolism, and survival.

Overview

The PI3K/AKT/mTOR signaling pathway is a central regulator of cell growth, metabolism, and survival. It is frequently activated in cancer and is a major target for therapeutic intervention.

Key Components

  • PI3K — Phosphorylates PIP2 to PIP3 at the plasma membrane
  • AKT — Central node that phosphorylates numerous downstream targets
  • mTOR — Forms mTORC1 and mTORC2 complexes regulating protein synthesis
  • PTEN — Tumor suppressor that dephosphorylates PIP3

Related Articles

MAPK/ERK Signaling Pathway

The MAPK/ERK pathway is a critical signaling cascade that regulates cell proliferation, differentiat...

Wnt/β-Catenin Signaling Pathway

The Wnt/β-catenin pathway regulates cell fate determination, proliferation, and stem cell maintenanc...

JAK/STAT Signaling Pathway

The JAK/STAT pathway mediates cellular responses to cytokines and growth factors.
Back to Signaling Pathways All Research Areas
🏅
Certified
ISO 9001:2015
🌐
Shipping to
140+ Countries
📦
Delivered
1,000,000+ Orders
🔬
Validated
50,000+ Products
⚡
Dispatch
Within 24 Hours