Immunohistochemistry (IHC)

IHC-P and IHC-Fr protocols

Immunohistochemistry Protocol

Detection of antigens in tissue sections using LabReCon antibodies.

Paraffin-Embedded Sections (IHC-P)

  1. Deparaffinize in xylene, 2×5 min
  2. Rehydrate through graded ethanol (100%, 95%, 70%)
  3. Antigen retrieval: heat in citrate buffer pH 6.0, 20 min
  4. Block endogenous peroxidase with 3% H₂O₂, 10 min
  5. Block with 5% normal serum, 30 min
  6. Incubate with primary antibody (1:200) overnight at 4°C
  7. Incubate with HRP-conjugated secondary, 30 min at RT
  8. Develop with DAB substrate, 5-10 min
  9. Counterstain with hematoxylin
  10. Dehydrate and mount
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